Adam Kibel, MD, Awarded a $3.4M National Institutes of Health Grant

Dr. Kibel has been awarded by the National Institutes of Health and the National Cancer Institute for his study, “Polygenic risk stratification combined with mpMRI to identify clinically relevant prostate cancer.”

The premise of this study is that an optimal early detection strategy to identify clinically relevant prostate cancer will involve a two-tiered algorithm that leverages inherited genetic information to determine who is at risk for prostate cancer followed by MRI imaging to determine which of these high-risk patients has clinically relevant disease. We propose to test this premise by implementing a polygenic risk score in men and conducting a prospective trial among 1,500 men with MRI to prove the two-tiered algorithm works. Collaborators include: Harvard T.H. Chan School of Public Health, Howard University Cancer Center, The Center for Cancer Research of the NCI, The Division of Cancer Epidemiology and Genetics (DCEG) of the NCI, and the Center for Prostate Disease Research of the Uniformed Services University of Health Sciences (USU), Walter Reed National Military Medical Center (WRNMMC), Murtha Cancer Center Research Program (MCCRP) and Urology Service at WRNMMC.

Adam S. Kibel, MD
Chief, Division of Urology, Brigham and Women’s Hospital
DiNovi Family Distinguished Chair in Urology
, Brigham and Women’s Hospital
Elliott Carr Cutler Professor of Surgery in Urology, Harvard Medical School

Dr. Kibel is chief of Urology at Brigham and Women’s Hospital and Dana-Farber Brigham Cancer Center and the inaugural incumbent of the DiNovi Family Distinguished Chair in Urology at Brigham and Women’s Hospital. He received his undergraduate and medical degrees from Cornell University, completed his urology residency at the Harvard Urologic Surgery Residency Program and fellowship training at the Johns Hopkins Brady Urological Institute.

With a practice focused on minimally invasive treatments for urologic cancers, Dr. Kibel has been listed as one of America’s Top Doctors by Castle Connolly and named a top urologist by Boston Magazine. The author of close to 400 peer-reviewed publications, Dr. Kibel’s research focuses on the identification of molecular markers of urologic tumors, adjuvant and neoadjuvant approaches to treatment of aggressive disease, and improved imaging of patients with urologic malignancies. His research has been supported by multiple organizations including the National Cancer Institute, the American Cancer Society, the American College of Surgeons and the American Foundation for Urologic Disease.

Indranil Sinha, MD, Awarded $2.1M National Institutes of Health Grant

Dr. Sinha was awarded for his project, “PHD2 mediated loss of hypoxia signaling limits skeletal muscle regeneration and exercise response in aging.”

The study evaluates the role of the hypoxia signaling pathway in age-related decline in skeletal muscle regeneration and response to exercise.  The goal is to identify drug targets to limit loss of skeletal muscle function in the elderly population.

Indranil Sinha, MD
Director of Research, Division of Plastic and Reconstructive Surgery
Associate Professor of Surgery, Harvard Medical School

Dr. Sinha is an associate professor of surgery at Brigham and Women’s Hospital.  He received his bachelor’s degree from the University of California, Berkeley in molecular and cellular biology, and completed his medical degree at the University of Michigan Medical School, followed by a plastic surgery residency from the Harvard Combined Program.  His research focus is the rejuvenation of skeletal muscle function in aging and following traumatic injury.

Department of Surgery Faculty Members Among Boston’s Top Doctors 2023

61 Department of Surgery faculty members have been named “Top Doctors” by Boston magazine this year.  Congratulations to the following providers for being recognized as the best in their respective fields.

Colon and Rectal Surgery
Ronald Bleday, MD
Joel Goldberg, MD, MPH
James Yoo, MD

Otolaryngology
Donald Annino, MD
Regan Bergmark, MD 
Thomas L. Carroll, MD
Carleton E. Corrales, MD
Laura A. Goguen, MD
Stella Lee, MD
Alice Z. Maxfield, MD
Anthony Prince, MD
Eleni Rettig, MD
Rachel E. Roditi, MD
Jennifer Shin, MD, SM
Ravindra Uppaluri, MD, PhD

Plastic Surgery
Matthew Carty, MD
Yoon Chun, MD
Dennis Orgill, MD, PhD
Andrea Pusic, MD
Christian Sampson, MD (Hand Surgery)
Simon Talbot, MD

Surgery
Stanley Ashley, MD
Monica Bertagnolli, MD
Thomas Clancy, MD
Gerard Doherty, MD
Laura S. Dominici, MD
Hassan Khalil, MD
Tari King, MD
Sayeed Malek, MD
Elizabeth Mittendorf, MD, PhD
Faina Nakhlis, MD
Chandrajit Raut, MD, MSc
Esther Rhei, MD
Douglas Smink, MD, MPH
Ali Tavakkoli, MD
Ashley Vernon, MD

Thoracic and Cardiac Surgery 
Raphael Bueno, MD
Christopher Ducko, MD
Tsuyoshi Kaneko, MD
Hari Mallidi, MD
M. Blair Marshall, MD
Ciaran J. McNamee, MD
Steven Mentzer, MD
Daniel E. Rinewalt, MD
Matthew Rochefort, MD
Scott Swanson, MD
George Tolis, MD
Jon Wee, MD
Abby White, DO
Daniel Wiener, MD

Urology
Steven Chang, MD
Martin Kathrins, MD
Adam Kibel, MD
Mark Preston, MD
Graeme Steele, MD
Quoc-Dien Trinh, MD

Vascular Surgery
Michael Belkin, MD
Edwin Gravereaux, MD
Matthew Menard, MD
Louis Nguyen, MD, MBA, MPH
Charles Ozaki, MD