Dr. Raut has been awarded a $3.6M NIH grant for the study, “Supratherapeutic Paclitaxel Buttresses Reduce Locoregional Recurrence Rates Following Surgery for Soft Tissue Sarcomas.”
This study will evaluate investigator-designed, biphasic chemotherapy-loaded polymer films to determine if early, but not burst, release of physically entrapped paclitaxel followed by extended release of covalently-bound paclitaxel (1) will reduce locoregional rates and extend survival in patient-derived liposarcoma and leiomyosarcoma xenograft surgical models and (2) safely deliver drug locoregionally, achieving high local tissue drug levels with minimal systemic delivery when implanted in situ. This grant is a successor to a prior R01 by the same investigators.
Chandrajit P. Raut, MD, MSc
Chief, Division of Surgical Oncology, Brigham and Women’s Hospital
BWH Distinguished Chair in Surgical Oncology, Brigham and Women’s Hospital
Director, Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute
Professor of Surgery, Harvard Medical School
Dr. Raut is a committed clinician who specializes in the multidisciplinary care of patients with soft tissue sarcoma. He is also a prolific researcher and has a multi-PI R01 grant to evaluate an innovative drug-eluting film to be placed in the surgical bed and reduce tumor local recurrence rates. Additionally, he was co-PI on a multi-institutional phase II clinical trial evaluating five years of adjuvant imatinib for primary gastrointestinal stromal tumor (GIST), co-investigator on an international phase III randomized clinical trial evaluating the use of preoperative radiation therapy for retroperitoneal sarcomas and a member of The Cancer Genome Atlas Sarcoma (TCGA-SARC) working group of the National Institutes of Health (NIH)/National Cancer Institute (NCI).
Dr. Raut serves as section editor for sarcoma in the journals Cancer and Annals of Surgical Oncology, associate editor for the journal Sarcoma and editorial board member for the journal ACS Case Reports in Surgery. He has authored over 210 papers and over 30 book chapters.
Dr. Raut is a graduate of Stanford University (BA/BS), University of Oxford (MSc) and Harvard Medical School (MD). He completed a residency in general surgery at Massachusetts General Hospital followed by a fellowship in surgical oncology at MD Anderson Cancer Center.